Fisher made a successful transition to Hollywood in the live-action film adaptation of Scooby-Doo (2002), and has since achieved fame for her roles in Wedding Crashers (2005), Confessions of a Shopaholic (2009), The Great Gatsby (2013), and Now You See Me (2013). Her other notable film credits include I Heart Huckabees (2004), The Lookout (2007), Definitely, Maybe (2008), Burke & Hare (2010), Bachelorette (2012), Visions (2015), Grimsby, Nocturnal Animals, Keeping Up with the Joneses (all 2016), and Tag (2018). In addition, she has voiced characters in animated films such as Horton Hears a Who! (2008), Rango (2011), and Rise of the Guardians (2012). On television, she played a recurring role on the fourth and fifth seasons of Arrested Development (2013, 2018).
Fisher has authored two young adult novels and the Marge in Charge book series.