Mrs Tweedy is a selfish, cruel, cold-hearted woman who only uses the Chickens to get money, which she and her husband are very low on. She is always looking for a chance to bully Mr. Tweedy and the chickens, and despite her evilness, she does show cleverness at times-she is the one who comes up with the idea of buying a Pie Machine to use to make more profit from the Chickens. She can also show impatience with her husband, shown when she is contemplating buying the Pie Machine, and when the Pie Machine is broken. It is also hinted that her and her husband disagree on many things-when Mr. Tweedy is attacked by the chickens he calls to her "The chickens are revolting!" and she, doing other things at the time, says to herself "Finally, something we agree on." However, she didn't know he meant revolt in the context she was thinking of. She is also shown to be a very tough woman who is possibly happy with the idea of murdering the Chickens-when she is looking at Edwina at Roll Call she has an evil smile on her face, and we see a face similar to that when Ginger is going into the Pie Machine, and is seen killing Edwina and probably many Chickens before.
Mrs. Tweedy wears a maroon(ish) dress with an upright collar, a black brooch at the throat and black muck boots, she rolls the sleeves up at her elbow.
Mrs. Tweedy had long, dark brunette hair pulled back into a tight bun at the top of her head.
Mrs. Tweedy is one of DreamWorks' most cruel and humourless villains.
It's a pie machine you idiot. Chickens comes in, pies come out.
-Professor Melisha Tweedy
Chicken Pies you great lummox
-Professor Tweedy telling Mr Tweedy
Put the ramp down. You are going to be a pie.
-Mrs. Tweedy telling Ginger