"The world-famous talking moose and flying squirrel are back in The Adventures of Rocky and Bullwinkle, a comedy about two goofball friends who end up in harrowing situations but end up saving the day time and again. As their silly ambitions dovetail with Fearless Leader's sinister plans to take over the world, they are set on a collision course with his notorious super spies Boris and Natasha."
- Tara Strong as Rocky J. Squirrel
- Brad Norman as Bullwinkle J. Moose/Agent 1/Crab Monster/Bullwinkle Monster
- Ben Diskin as Boris Badenov/Pauly Bro / Flytrap 3 / Humongalon / Cute Monster /Alpha Bro / Manchester
- Rachel Butera as Natasha Fatale/Lady Bro/Pedestrian 1 /Flytrap 2
- Piotr Michael as Fearless Leader/Alpha Bro/Pedestrian 3 / Flytrap 4
- Daran Norris as Narrator/Pedistrian 2 /Flytrap 1/Evil Chicken
- Kari Wahlgren as Grandwinkle
- Fuschia! as Peachfuzz
- Rachel Butera as Agent 2
- Gordon Ramsay as Himself
- Ant Simpson as the Butter/Butler Monster/ Driver
- Grey Griffin as Dr Lesso
- Rhomeyn Johnson as Rafi Tusk
- Kevin Michael Richardson as President Leader
- Eric Bauza as Premier Leader
- Mario Lopez as Himself
- Faruq Tauheed as Mayor Grundstrom
- Walla as Monsters
- Eric Goldman as Vocalist
- Tom Kenny as Colonel Boudreaux
- Ben Giroux as Newsie
- This is the third Jay Ward reboot series followed by George of the Jungle and The Mr. Peabody & Sherman Show.
- Following June Foray's death in 2017, Tara Strong took over the voice of Rocky J. Squirrel.